8em All comments and suggestions are appreciated. The rarity of FOP suggests the likelihood of a single mutated locus causing the disorder in all or most individuals, and recent genome- wide linkage analysis in four small multi-generational families suggests linkage to a region on the long arm of human chromosome 4 .
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(1994). 459 B-37 (2R,3R)form NH2 N5 HOOC O N O CON H SPh NH H2N N Me NH2 265-295 (rev) Bis(methyl-4,6-O -benzyli- dene[2,3-b][2?,3?-k])-1,4,7,10,13, 16-hexaoxacyclooctadecane (2R ,3R )-form D -threo-form 1,2-Isopropylidene: 2-Deoxy-4,5-O-isopro- pylidene-D-threo-pent-1-enose diphenyl dithioacetal [37107-88-3] C20H22O3S2 374. 23). 6 Substitution Reactions of Ethers 451 PROBLEM 11 Propose a mechanism for each of the following reactions: a.
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